For those that are not eligible for CRS-HIPEC, systemic chemotherapy should be used. The most effective agent for MPM has been pemetrexed, with either cisplatin or carboplatin. Failure to obtain disease control should prompt a switch to another regimen such as cisplatin with irinotecan, gemcitabine with cisplatin/carboplatin, or vinorelbine alone. Another alternative for second-line systemic treatment is the use of a molecular agent, such as tremelimumab. All of these second-line therapies are still under investigation and enrollment in clinical trials could be beneficial.National Library of Medicine
You might have to make further choices as your situation changes. It helps to find out as much as possible each time. You can stop a treatment whenever you want to if you find it too much to cope with.Peritoneal mesothelioma is the name given to the cancer that attacks the lining of the abdomen. This type of cancer affects the lining that protects the contents of the abdomen and which also provides a lubricating fluid to enable the organs to move and work properly.
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Experts do not wholly understand how asbestos causes mesothelioma. Mesothelioma researchers say the following process may lead to peritoneal mesothelioma: Common intravenous chemotherapy drugs for mesothelioma are pemetrexed and cisplatin.